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Estrace (Estradiol)

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Estrace is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected

Other names for this medication:
Bestradiol, Conjugase, Divigel, Edval, Espauz, Estogen, Estraderm, Estradiol, Estrofem, Evafem, Evalon, Evaride, Menocare, Mixogen, Oestrogel, Premarin, Progynon, Progynova, Sandrena

Similar Products:
Lioresal, Mellaril, Glucotrol, Viagra, Acticin, Luvox, Cordarone, Baccidal, Egeria, Levonix, Regtin, Ecsit, Trimethazol, Zolpirest, Glimiprex, Clophene,

Also known as: Estradiol


Estrace is used to treat symptoms of menopause (hot flashes, vaginal dryness, burning and irritation), prevent osteoporosis. Estrace is sometimes used as part of cancer treatment in women and men. Estrace medication is a form of estrogen - female hormone necessary for many processes in the body. Estrace works by replacing natural estrogens in a woman who can no longer produce enough estrogen. Estrace works for advanced prostate cancer by antagonizing male hormones. Estrace is also known as Estradiol.


This section provides information on the proper use of a number of products that contain estradiol. It may not be specific to Estrace. Please read with care.

It is very important that you use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

This medicine is to be used only in the vagina. Use it at bedtime unless your doctor tells you otherwise.

This medicine comes with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

To use the vaginal ring:

This medicine is contained in a ring that you or your caregiver will put into your vagina. The ring will slowly release small amounts of medicine for your body to absorb. Your caregiver will show you how to insert the ring. Do not remove the ring from the sealed pouch until you are ready to use it. Once the ring is in place inside your vagina, you should not be able to feel it. If you feel uncomfortable, the ring may not be inserted far enough. Gently push the ring farther into your vagina. If you feel pain, talk to your doctor. You will leave the ring inside for 90 days (3 months), unless your doctor tells you a different schedule. After that time, remove the ring and insert a new one. If you forget to remove the ring after 90 days, call your doctor for instructions. The ring may move down into the lower part of your vagina accidently. This can happen if you strain to have a bowel movement. Use your finger to gently push the ring back into place. If the ring comes all the way out of your vagina, rinse it off with warm water and put it back in. Call your doctor if the ring comes out several times. If you need to remove the ring, hook your finger through the ring and pull it out.

To use the Imvexxy™ vaginal insert:

The insert should be used only in your vagina. Do not swallow. Keep your hands clean and dry while handling the insert. Push an insert through the foil of the blister package and hold it with the larger end between your fingers. You may choose to put the insert into your vagina using the lying down or standing up position. Put the insert about 2 inches into your vagina, with the smaller end up, using your finger. Most women will start by using a new insert every day for two weeks, then change to using a new insert only 2 days each week. Carefully follow the schedule that your health caregiver tells you to.

To use the Vagifem® vaginal insert:

The tablet should be used only in your vagina. Do not swallow the tablet. Each vaginal tablet comes packaged inside an applicator. Do not take the tablet out of the applicator. If the tablet comes out of the applicator but has not fallen out of the package, carefully put it back into the applicator for insertion. If the tablet falls out of the applicator, throw it away and use a new applicator that still has the tablet inside it. Keep your hands clean and dry while handling the tablet. Take the applicator out of the plastic wrap before using it. Use the applicator only one time and then throw it away. Use a new applicator for each dose. Most women will start by inserting a new tablet every day for two weeks, then change to inserting a new tablet only 2 days each week. Carefully follow the schedule that your health caregiver tells you to.

To use the Divigel®:

Open the packet and use the entire contents of a packet on the skin of either right or left upper thigh once a day. Apply the gel to the right or left upper thigh on alternate days to avoid potential skin irritation. Do not apply the gel on the face, breasts, or irritated skin or in or around the vagina. Allow the gel to dry after application before dressing. Avoid fire, flame, or smoking until the gel has dried. Do not wash the application site within 1 hour after applying the gel. Avoid getting the gel into your eyes. Wash your hands after each application.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of this medicine that is absorbed in the body.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For vaginal dosage form (gel): For atrophic vaginitis, hot flashes, and other symptoms caused by menopause: Adults—At first, 0.25 grams applied on the skin of either right or left upper thigh once a day. Your doctor may adjust your dose as needed up to a maximum of 1.25 grams once a day. Children—Use is not recommended. For vaginal dosage form (ring): For atrophic vaginitis, hot flashes, and other symptoms caused by menopause: Adults—One vaginal ring inserted into the vagina for 3 months. Your doctor may adjust your dose as needed. Children—Use is not recommended. For vaginal dosage form (insert): For treatment of atrophic vaginitis caused by menopause: Adults—10 micrograms (mcg) or one insert into the vagina once a day for 2 weeks, followed by one insert 2 times a week. Children—Use is not recommended. For treatment of painful sexual intercourse caused by menopause: Adults—At first, 4 micrograms (mcg) or one insert into the vagina once a day for 2 weeks, followed by one insert 2 times a week (every 3 to 4 days). Your doctor may adjust your dose as needed. Children—Use is not recommended.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Estrace are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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In addition, when activated beta-catenin and c-Met were coinjected into CCND1-null mice, liver tumors developed despite the absence of CCND1. Two hundred and fifteen of 219 permanent residents of Kunde were studied. These dimensions were determined to be similar to those discovered through a previous urban study, indicating that there may be considerable overlap between good deaths in rural and urban areas. Pharmacovigilance of malaria intermittent preventive treatment in infants coupled with routine immunizations in 6 African countries. The spatial resolution of current laboratory-used micro-CT systems has come down over the last years from a few tens of microns to a few microns. pylori-associated ulcers include those due to non-steroidal anti-inflammatory drugs, Zollinger-Ellison syndrome, and those related to other forms of gastritis. TS and DHFR protein levels had a mean total expression score of 1 and 3 in MPM patients.

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Higher order aberrations (HOAs) were measured in 54 anisometropic amblyopic children using the ZY-WAVE II aberrometer. This decrease was more pronounced in laminae receiving crossed fibers. The management of oral anticoagulant therapy needs regular monitoring of INR, which should be kept in the narrow therapeutic range of 2.0-3.0 most of the time, with adjustments of the dose as required. Dextrane 250 increases red blood cells aggregation and induces blood hyperviscosity at low flow rates. Immunohematological aspects of total body irradiation and bone marrow transplantation for the treatment of leukemia. The main clinical advantage of this time-consuming procedure was the ability to determine the localization within the catheters of individual temperature measurement points of multipoint thermistor probes. The regime of methyl prednisolone that produced maximal suppression of meningeal inflammation (30 mg/kg/day) did not alter CSF chemotactic activity or chemotactic responsiveness and phagocytic activities of granulocytes from rabbits with meningitis.

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Preliminary note on the acarological fauna of dust from mattresses in Algeria. Antigen-capture ELISA for viral haemorrhagic septicaemia virus serotype I. The finding offers a potential approach to produce desirable cell types from ES cells, useful for regenerative cell therapy. In the present study, we used radioiodinated Bpa8-SP to covalently label with high efficiency the rat SP receptor expressed in a transfected mammalian cell line. Thrombin binding studies in the high affinity range showed 1,500 sites for the Bernard-Soulier platelets as against 4,000 for normal controls. Lipid-based physiologically based toxicokinetic models are a subset of PBTK models that can simulate concentrations of highly lipophilic compounds in tissue lipids, without the need for partition coefficients. In patients without diabetes recruited from November to April, 25OHD levels were significantly lower than those from May to October, whilst patients with diabetes did not show a significant seasonal variation.

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Commercial) as well as other key activities during product commercialization (process scale-up, technology transfer, and process improvement). Antinuclear antibodies (ANA) and anti-lamin C antibodies recognize antigens of the nucleus and the nuclear lamina, respectively. Experimental design: parenteral contraceptives in the rhesus monkey. Defective simian virus 40 genomes: isolation and growth of individual clones. Unprecedented, low cytotoxicity of spongelike calcium phosphate/poly(ethylene imine) hydrogel composites. Patients who underwent bronchoscopy with certain bronchoscopes after they had been repaired by a third-party vendor. Five varieties of canned fish and hair specimens from 243 subjects in Port Moresby have been analysed for organic and total mercury. Changes in vascular resistance were determined by calculating changes in abdominal aortic perfusion pressure, and changes in capacitance by integrating the changes in venous outflow.

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The beta index, which estimates both temporal and spectral dissimilarities, is linearly linked to the number of unshared species between acoustic communities. Finally, we investigated cyclooxygenase-2 (COX-2) expression in RPE cells exposed to UVA radiation, and EGCG was found to also have inhibited UVA-induced COX-2 expression. The serum carotene concentration dropped off after the age of one year and remained low until two years of age. The mitogenome (17,111 bp) comprises 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and 1 putative control region. The role of PRL in mediating the haloperidol-induced increase in tuberoinfundibular dopamine synthesis rate was assessed by studying the effects of administration of PRL antiserum.

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The results show that prophylactic lithium treatment does not affect renal cortical function adversely in the majority of patients, but impaired renal concentrating ability is a common accompaniment. Telomerase suppression initiates PML-dependent p53 activation to inhibit bladder cancer cell growth. Although long considered a dedicated regulator of larval cell death, we find that E93 is expressed widely in adult cells at the pupal stage and is required for many patterning processes at this time. Psychological and social factors in how many zyrtec pills should i take undergoing reconstructive surgery among individuals with craniofacial conditions: an exploratory study. However, few reports to date have shown significant numbers of patients collected on a multicenter basis. Disappearance of paternal histocompatibility antigens from hybrid mouse blastocyst at the time of implantation. Dogs, distemper and osteitis deformans: a further epidemiological study. Usefulness of several methods of investigation in the diagnosis of renovascular hypertension.

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The hyper IgE could be due to the defect of IgE receptors on the cell membrane of mast cells of dysfunction of T and/or B cell. IgA (kappa)-IgG cryoglobulinemia and hyperviscosity syndrome in a patient with necrotizing tissues. Impact of fathers on risky sexual behavior in daughters: a genetically and environmentally controlled sibling study. In some instances, a hyperactive state of the animal followed intraventricular injections of angiotensin II. (Temple, 1992), who had intact verbal but impaired visual episodic memory. Effects of intraduodenal administration of a low dose of cholecystokinin (CCK) antagonist (CR-1505) on plasma CCK concentration, intestinal CCK content, and levels of CCK mRNA. However, so far, no technique has been validated to monitor the compliance of intracerebral arteries (Ca) in patients with carotid artery disease. In fasted individuals the mean maximum penicillamine level in plasma of 3.05 mcg/ml occurred at 3.8 h, and the area under the 0-12 h plasma curve was 14.7 mcg/h/ml. Eleven days following the administration of docetaxel: 30 mg/m2 and nedaplatin: 30 mg/m2, the patient developed TLS (serum creatinine: 8.57 mg/dL, uric acid: 11.0 mg/dL, serum potassium: 6.3 mEq/L, serum phosphorus: 7.18 mg/dL). Discriminant analysis (DA) is a family of statistical methods in which the primary purpose is to predict into which of several discrete groups (eg, diagnostic categories) an individual subject should be classed.

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Cardiac glycosides such as digoxin and their endogenous counterpart digoxin-like immunoreactive factor (DLIF) may possess anti-inflammatory properties. The maturation of the auditory brainstem response compared to peripheral nerve conduction velocity in preterm and full-term infants. A community sample of 187 black and white mothers and fathers were interviewed with regards to their parenting practices using both quantitative and qualitative approaches. he position of the shoulder affects target coverage and critical structure dose, and may therefore be a concern during the setup of head and neck patients, particularly those with low neck primary disease. A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis. Changes in calmodulin and its mRNA accompany reentry of quiescent (G0) cells into the cell cycle. This study was undertaken to determine the absolute bioavailability and steady-state concentrations of moclobemide after doses of 150 mg.

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Chloride-citrate-glucose solution was used in fibrinogen preparation for intravenous administration. The definitive indication for embolectomy was occlusion of the main pulmonary artery of more than 50 percent as well as occlusion of the right or left pulmonary artery. Graded doses of gamma-irradiation up to 100 Gy had no effect on the extracellular release of 59Fe in AM cultured at 4 and 37 degrees C for 8-72 hrs postirradiation. RP may be classified by genetic type (single cases without known affected relatives should be termed isolated or simplex), by the topography of retinal involvement, and by the severity of disease (to identify subtypes with mild or localized disease). Selective separation of patchouli alcohol from the essential oil of Cablin potchouli by inclusion crystalline method. Assessment of the condition of the population of gonococcal cultures. The Custom NX 36 Drug Eluting Stent (DES) System is designed to treat coronary lesions via in situ stent length customisation.

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In essence, the type of inhibition depends on the relative rates and extent of TPO inactivation and drug oxidation. marcescens were genotypically characterized with random amplified polymerase chain reaction (RAPD-PCR)-fingerprinting. Aldolase and -glycerolphosphate and 3-phosphoglycerol aldehyde dehydrogenase activity of rabbit muscles in experimental atherosclerosis. Plasmodium knowlesi, a simian malaria parasite, has been reported in humans in many Southeast Asian countries. Immunoelectron microscopy confirmed the immunohistochemical data of normal lung tissue obtained at the light microscopic level. Testes are determined by the activity of the testis determining factor encoded by the sex determining gene, Y (SRY) located on the Y chromosome.

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Treading carefully: a qualitative ethnographic study of the clinical, social and educational uses of exercise ECG in evaluating stable chest pain. It appears, therefore, that poles share a common antigen(s) with cylindrical regions of the cell. Satisfactory execution of CPR required performance of both adequate compressions and ventilations in conformity with current American Heart Association guidelines. The L-chain was isolated by gel filtration after partial reduction and alkylation of the IgA-molecule. Spinal synovial cyst: case report using magnetic amaryl tablets resonance imaging. In this paper, the contributions, mainly in the last 5 years, on the enzymatic reactors and their applications in proteome study are reviewed, with some newly developed inorganic and organic carriers for enzyme immobilization described in details.

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The structure of the receptors in the ganglia and that of the sympathetic contacts are compared, the latter are predominantly axodendritic. Pathologic findings from the National Surgical Adjuvant Project for Breast Cancers (protocol no. Focal neurologic signs developed in a 75-year-old woman who had presented with encephalitis. Activity and behavioral development in stunted and nonstunted children and response to nutritional supplementation. Further investigation revealed that such suppression was due to translational arrest rather than mRNA degradation. Biomass and product yields strongly depend on the C-source of the inoculation culture. Religious faith and use of complementary and alternative medicine (CAM) in a nationwide cohort of women treated for early breast cancer. These results suggest that microsatellite analysis, which in principle can be performed at about one-third the cost of cytology, may be a useful addition to current screening methods for detecting bladder cancer. Light microscopy revealed cotton-wool spots which were identical to those observed in man with a collection of swollen axons containing densely staining pseudonuclei.

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