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Nucalm (Alprazolam)

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Nucalm is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Nucalm, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Nucalm is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aderta, Alcalm, Aldep, Alfix, Almac, Alpraquil, Alprasert, Alprine, Alprowon, Alrif, Alsert, Alzep, Anlzium, Anquil, Anxigon, Azoslip, Balzam, Cozac, Depten, Esteem, Eurolam, Ezoprax, Flumusa, Flunix, Mebasap, Nexlpra, Nokzok, Nucalm, Pecalm, Pifzot, Plxna, Prosanti, Restyl, Romipraz, Selam, Selamb, Silam, Tenolam, Tenrid, Trapose, Trika, Welnorm, Wycalm, Zenax, Zeprax, Zolorest, Zomark, Zorest

Similar Products:
Amoxil, Leukeran, Motilium, Zocor, Norvasc, Risperdal, Neoral, Skelaxin, Diamox, Albstat, Lanex, Maxalt, Lipex, Pocital, Detine, Doxazosin, Ribavirin, Velpo,

Also known as: Alprazolam


Nucalm XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Nucalm XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Nucalm XR may also be used for other purposes not listed in this medication guide.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Nucalm XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of alprazolam can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Nucalm are:

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Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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In this case report, 3D visualization resulted in a faster and clearer understanding of the unique anatomical situation in a patient with complicated liver anatomy than transversal CT images. suggests that the prolonged antiacne effect of PDT relies on factors independent of bacterial density. Nasoenteral feeding tube placement with the Seldinger technique using transoral endoscopy is a tedious procedure. Both skin and kidney allografts were at least partially protected from rejection by daily treatment with 1-0 mg/kg of prednisolone acetate. Patients in the age group of 10 to 19 years had the highest percentage of graft failures. Quality of life in persons living with HIV in Burkina Faso: a follow-up over 12 months. Our goal was to perform a pilot study to assess the effectiveness and tolerability of a topical lidocaine patch (Lidoderm) for the treatment of peripheral neuropathic pain conditions other than postherpetic neuralgia. The expression of Wnt5a gene in specimen of 31 cases and three leukemic cell lines (Jurkat, K562, HL-60) were detected by RT-PCR. These results show that this form of early life stress results in an altered brain-gut axis and is therefore an important model for investigating potential mechanistic insights into stress-related disorders including depression and IBS.

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Of the three survivors, one had mental retardation and cerebral palsy and the other two had minor disabilities. Even though the data shows large variability among the bifurcations within the same generation, there is a general trend for the data obtained in these two replicas. We therefore analyzed the relationships between the common LMNA 1908T/C single nucleotide polymorphism (SNP) and plasma leptin and anthropometric indices in 306 nondiabetic Canadian Oji-Cree. Here, we report on the elevation and soil-type dependence of forest canopy chemistry among 75 compositionally and environmentally distinct forests in nine regions, with a total of 7819 individual trees representing 3246 species collected, identified and assayed for foliar traits. Patients who were admitted to our hospital for CAP were older and had more comorbidities with a much higher incidence of Gram-negative pathogens than in a previous study. Using this approach, we identify important gene clusters so far not appreciated by standard microarray techniques.

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Thick-skinned, glandular skin areas, such as the nasolabial fold and chin, were found to be substantially smoother in the laser-treated areas. A note on sodium salicylate and tissue 5-hydroxytryptamine in the rat. Herein, we have used addition of an indifferent electrolyte to perturb few-layer graphene dispersions in a nonaqueous solvent (1,2-dichloroethane) as a way to probe the importance of interparticle electrostatic repulsions toward the overall dispersion stability. In response to alterations in the extracellular environment, signal transduction pathways target transcription factors, transcriptional coregulators and chromatin-modifying factors, leading to their phosphorylation by protein kinases or dephosphorylation by protein phosphatases. We randomly assigned 501 patients (all of whom had stage III or IV disease with no distant metastases and tumors considered to be unresectable or were candidates for organ preservation) to receive either TPF or PF induction chemotherapy, followed by chemoradiotherapy with weekly carboplatin therapy and radiotherapy for 5 days per week. Twenty-two of the dialysis patients received daily oral multivitamin supplementation containing 10 mg vitamin B6, 6 micrograms vitamin B12, and 1 mg folic acid during the last year before the study started.

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A bibliometric analysis of the Farmacia Hospitalaria journal (2001-2006). Partially hydrolyzed guar gum characterization and sensitive quantification in food matrices by high performance anion exchange chromatography with pulsed amperometric detection--validation using accuracy profile. At certain modulation depths this noise is almost totally relegated to the quadrature channel. Alcohol-related injuries are significantly more serious than non-alcohol-related injuries. The T cell-derived enhancing factor(s) has been shown to affect allogeneic as well as isogeneic T and B cells. Using questionnaires, we collected information on musculoskeletal disorders and potential risk factors from 751 nurses employed in public hospitals.

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In general, post-TBI drivers have a higher occurrence of multiple crashes and this should be further explored to guide driver rehabilitation, evaluation, and training. The tendo-osseous plantaris graft is, according to this research, amenable to be used as a viable choice in reconstruction of secondary flexor tendon injuries related to its length shape and size and especially due to the bone stock adequate to strong phalanx fixation. Our results showed that studies performed with a slice thickness of 1.0 or 1.25 mm produced similar image quality to those with a thickness of 0.5 or 0.625 mm. The dye-guided and gamma probe-guided methods were complementary. Cytological analysis revealed that the normal structure of the spleens of tumor animals was infiltrated by myeloid elements. Comparison of the relative dissipation rates of endosulfan pesticide residues between oolong and green tea.

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Negative pressure wound therapy has become an increasingly important part of wound management. Synthesis and characterization of authentic standards for the analysis of ribofuranose-containing carbohydrates by the reductive-cleavage method. n hypertensive patients treated with beta-blockers, 3 weeks of nightly melatonin supplementation significantly improved sleep quality, without apparent tolerance and without rebound sleep disturbance during withdrawal of melatonin supplementation (in fact, a positive carryover effect was demonstrated). Between April 2011 and May 2012, 5 cases underwent thoracoscopic thymectomy using this method. Our case was a 19-year-old woman, who was diagnosed postoperatively with follicular variant of papillary thyroid carcinoma in a mature cystic teratoma. Psychosocial experiences of breast cancer survivors involved in a dragon boat program: exploring links to positive psychological growth. Behavioral neuroscience: challenges for the era of molecular biology.

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Differences in immediacy between traditional and nontraditional students. The factor with the greatest influence on biochemical recurrence when it comes to surgery and high and very high-risk prostate cancer is the presence of a positive margin, followed by the Gleason score. This study reports the development and validation of an amniotic fluid model using an Arbitrary Lagrangian Eulerian formulation in the LS-DYNA environment. Fifty years of tsetse control in Tanzania: challenges and prospects for the future. The real-time PCR assays provided a rapid method for detection and one-step genotyping of G.

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She underwent subtotal resection of the tumor, resulting in improvement of her symptoms. Neurological examination revealed severe paraparesis (1/5), sensory disturbance below Th10, neurogenic bladder and absence of patellar and achilles tendon reflexes. Although facial motor neurons are known to develop within hindbrain rhombomere 4 (r4) and r5, the precise origins of branchiomotor and visceral motor neuron subpopulations are unclear. This paper summarizes the outcome of a study carried out by Politecnico di Milano and LEAP with the support of Actelios SpA on the prospects of a technology based on sequential gasification and combustion of this specific waste stream. At critical memory length, a Hopf bifurcation leads to the formation of stable limit cycles. Cytokine-regulated secretion of nerve growth factor from cultured rat neonatal astrocytes. Dosed resection of PALV and its plasty by the Dor-II Jatene method allowed the LV cavity geometry to be reestablished and thus the MV fibrous ring sizes to be reduced as well as the degree of the valve insufficiency. We investigated immunohistochemically the localization of the terazosin 2mg tab price binding sites of the enterotoxin in the preparation under the conditions in which the enterotoxin reduced maximally the amplitudes of the twitch tension elicited by electrical stimulations to the phrenic nerve. The preclinical rationale explaining this efficacy is that it inhibits the growth of BAC cell lines in vitro. We present a rare pathological entity of the liver and review the literature.

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One hundred and fifty-two patients with early stage lung cancer completed measures of self-efficacy, pain, fatigue, quality of life, depression, and anxiety. This report documents a new case of multiple cutaneous bronchogenic cysts bilaterally located on the neck and on the scalp, which are unusual locations of this lesion. Role of insulin receptor substrate-2 in interleukin-9-dependent proliferation. Changes in the gabapentin neurontin 300 mg side effects beta-adrenergic receptor (beta-AR) system such as receptor down-regulation, uncoupling from G-proteins, receptor internalization and receptor degradation may account for some of the abnormalities of contractile function in this disease. The SH2 domains of inositol polyphosphate 5-phosphatases SHIP1 and SHIP2 have similar ligand specificity but different binding kinetics. Personal alarms have many positive impacts on the lives of older people.

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It was concluded that nitric oxide can modulate non-selective cation channel activity by oxidizing sulfhydryl groups and that this effect can be reversed by reduction. The HPV-16 E7 protein is known to decrease levels of free RB in cells. The expression for the geometric phase for mixed state reduces to well known formulas in the pure state case when a system undergoes noncyclic and unitary quantum evolution. We prilosec dosage dogs previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. Phantom studies demonstrate feasibility of this platform for NSC imaging. All abusers had extensive focal chronic intersititial inflammatory infiltrates. Primary cardiac liposarcoma causing cardiac tamponade: report of a case. A system is described for the estimation of volumetric flow in arteries in real time by the simultaneous processing of the audio output of a commercial ultrasound scanner carrying the Doppler signal, and the video output carrying B-mode images of the lateral view of the artery. Isolated bone involvement in this disease is very rare, especially in children.

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CIL is a multi-step process that is driven by the tight coordination of molecular machinery. Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. The purpose of this study was to understand the cardiac consequences of different PVC burdens and the minimum burden required to induce left ventricular (LV) dysfunction. The tone-increasing property developed in the shed blood may, therefore, so far as the four test objects included in the present survey are concerned, be looked upon as especially affecting the blood vessels and probably their smooth muscle directly. CoMoDo: identifying dynamic protein domains based on covariances of motion. The multisubunit, non-lysosomal proteinases known as proteasomes have been implicated in the generation of these peptides. The influence on organ movements and levaquin 750 mg dosage dose allocation of the organs at risk is unknown. The recently demonstrated control over light distribution through turbid media based on real-time three-dimensional optoacoustic feedback has offered promising prospects to interferometrically focus light within scattering objects. In parallel, the developmental expression of the transcription factors cPhox-2 and Cash-1 was analyzed by in situ hybridization.

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Faecal specimens from 51 infants free of cystic fibrosis (CF) and from 9 infants with the disease were analysed for albumin and alpha1-antitrypsin content. STIFDB-Arabidopsis Stress Responsive Transcription Factor DataBase. Intermittent or inadequate discharge of bacteria from the renal parenchyma is suggested as the major source for this inaccuracy. A dynamical model improves reconstruction of handwriting from multichannel electromyographic recordings. Additionally, evidence suggests that CR3 also participates in the degradation of pRb. Epitrochlear lymph node metastases from invasive ductal breast cancer. In this study, we screened, using FGFR3 as a bait, a random 12-peptide phage library and obtained 23 positive clones that share identical amino acid sequences (VSPPLTLGQLLS), named as peptide P3.

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Molecular Insight into Different Denaturing Efficiency of Urea, Guanidinium, and Methanol: A Comparative Simulation Study. Time-domain soliton filter based on a semidissipative dual-core fiber. This enabled identification of restricted groups of highly correlated probe sets from an initial list of 1,372 previously published by our group. Focal application of SKF 81297 between recording sites increased the repetition rate of EFP, but reduced the amplitude as well as the duration of epileptic discharges. In the children infected in utero, specific IgA was detected more frequently than IgM. Basic testing of the prototype should be completed in 1977, with extensive studies to qualify the device for clinical use running at least into the early 1980s. Visually significant secondary cataract developed in nine eyes with intact posterior capsules, and seven eyes required Nd:YAG laser posterior capsulotomy. Comparative studies of microbial populations in the rumen, duodenum, ileum and faeces of lactating dairy cows.

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Sustained activation of Erk1/2 MAPK and cell growth suppression by the insert-negative, but not the insert-positive isoform of the human calcitonin receptor. Ground- and Excited-State Geometry Optimization of Small Organic Molecules with Quantum Monte Carlo. In all patients, there was increased lesion conspicuity and better definition of lesion extent on the diffusion-weighted images compared with the CT and T2-weighted MR images. We summarise published and recent research concerning the role of the nm23 gene in metastasis and normal cellular differentiation. Rotation of the 5-F pigtail catheter was performed with an electric drive or a handle. However, little is known about the molecular mechanism underlying the regulation of PPM1K gene expression. Very few bacilli are lost in the discarded material and we have repeatedly obtained 2.5 to 3 gm wet weight of M. It is proposed that the present myoclonus is a variant of brainstem reflex myoclonus in which arterial pulses served as intrinsic trigger stimuli via the carotid sinus and the medullary reticular formation.

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