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Odivir (Efavirenz)
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Odivir

Odivir is an antiretroviral medication used to treat and prevent HIV/AIDS. It is generally recommended for use with other antiretrovirals. It may be used for prevention after a needlestick injury or other potential exposure.

Other names for this medication:
Cytocom, Duovir, Efavir, Efavirenz, Efcure, Efferven, Emduo, Estiva, Evirenz, Lamivir, Lazid, Odivir, Retrodel, Revenz, Tenola, Trioday, Trustiva, Viraday, Viranz, Virocmb, Virolis, Vonavir, Zidolam

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Also known as: Efavirenz

Description

Odivir is used to treat HIV infection in combination with other anti-HIV medications. If Odivir is the only drug you take to treat HIV infection, it may stop working. Odivir is an oral medication that is used for the treatment of infections with the human immunodeficiency virus (HIV). It is similar to nevirapine (Viramune) and delavirdine (Rescriptor). Odivir is also known as Efavirenz, Stocrin. Odivir is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), zidovudine (Retrovir), didanosine (Videx), and lamivudine (Epivir). During infection with HIV, the HIV virus multiplies within the body's cells. The newly-formed viruses then are released from the cells and spread throughout the body where they infect other cells. In this manner, the infection continually spreads to new, uninfected cells that the body is continually producing, and HIV infection is perpetuated. When producing new viruses, the HIV virus must manufacture new DNA for each virus. Reverse transcriptase is the enzyme that the virus uses to form this new DNA. Odivir directly inhibits the activity of reverse transcriptase and blocks the production of DNA and new viruses. Unlike zidovudine, efavirenz does not need to be converted to an active form. Odivir does not kill existing HIV virus and it is not a cure for HIV.

Dosage

Take this drug by mouth, generally once daily as directed. Take on an empty stomach with a glass of water. Taking Odivir with food, especially a high-fat meal can lead to increased blood levels of the drug and increase your risk of having side effects. Best taken at bedtime during the first month of use. Using this drug regularly at bedtime may decrease certain side effects. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not take more or less of this drug than prescribed, or stop taking it unless directed to do so by your doctor. Read the patient information leaflet provided by your pharmacist. If you want to achieve most effective results do not stop taking Odivir suddenly.

Overdose

If you overdose Odivir and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Odivir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Odivir if you are allergic to efavirenz, or if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C.

Do not take with Atripla (combination efavirenz, emtricitabine, and tenofovir), unless your doctor tells you to.

Tell your doctor if you have ever had:

liver disease (including hepatitis B or C); long QT syndrome; a seizure; mental illness or psychosis; heart disease; or if you drink large amounts of alcohol or have a history of injection drug use.

Do not use Odivir if you are pregnant. It could harm the unborn baby or cause birth defects. Use 2 forms of birth control, including a barrier form (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy while you are using this medicine and for at least 12 weeks after your last dose. Tell your doctor if you become pregnant during treatment.

Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while you are taking Odivir.

HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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Isoflavones and phytosterols in XZK exert cholesterol-lowering effects in HFD mice through mechanisms that differ from those of lovastatin. Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin. We also measure the electric potential profile of partially suspended CNT devices at different gate biases, which shows that induced local fields can be imaged using the SPCM technique. We present the case of a 61-year-old woman suffering from the combination of these three side-effects. Autobiographical memories are a major feature of mental life in humans. To evaluate the possible effectiveness of bowel preparation on pain after hernia repair. Because the ACE inhibitor captopril and the angiotensin II receptor blocker saralasin attenuated increased in CBF during hypoxia, the findings suggest that endogenous release of angiotensin II contributes to the increase in CBF during hypoxia. A double-blind cross-over trial of Prenazone 600 mg and Aspirin 4 g daily was carried out on 20 patients suffering with rheumatoid arthritis.

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The role of screening coronary angiography in Asian Indian patients with rheumatic heart disease (RHD) due to undergo valve replacement surgery is unclear. Using computerized individual medication data to detect drug effects on clinical laboratory tests. Phenomena modeled include thought-induced attitude polarization, elaboration and attitude strength, motivated reasoning and social influence, an integrated view of heuristic versus systematic persuasion, and implicit versus explicit attitude change. Arrays of these sensors may be used in conjunction with pattern recognition techniques for purposes of analyte recognition and quantification. However, studies involving smaller sample sizes are inherently restrictive due to their limited statistical power to identify low frequency genetic variations. Assessing bioterrorism preparedness and response of rural veterinarians: experiences and training needs. Chemicals used to clean nappies have been suggested as a cause of sudden infant death syndrome (SIDS). We have discovered two somatic mutations in the VI transmembrane domain of the thyrotropin receptor gene in thyroid hyperfunctioning adenomas. The maximum occlusal force was calculated by using pressure-sensitive films.

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Tissue levels of prostaglandin E following heterotopic rat heart allografting. Long-term treatment with glutamine had positive effects on very old rats: (1) it prevented the loss of body weight, but, (2) it did not prevent the inevitable sarcopenia regardless of nutrition state, and (3) it maintained the gut mass. We prove that the point of expression of sex ratio does not affect the evolutionarily stable sex ratio for diploid hosts in populations infected with cytoplasmically inherited sex ratio distorters. Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica. Interestingly, in all American elavil 10 mg tablet picture populations, the same set of haplotypes O(1), O(1v), and O(1v(G542A)) was present, suggesting the following: (1) that they constitute the main genetic pool of the founding population of the Americas and (2) that they derive from the same ancestral source, partially supporting the single founding population hypothesis. An important problem in synthetic biology is to design a nucleotide sequence of an mRNA that confers a desirable expression level of a target protein. Hypoxia increased the IC(50) values for Pereskia grandifola and Orthosiphon aristatus extracts, but decreased the IC(50) values for Melastoma malabathricum and Carica papaya extracts. We performed a series of ADCC assays using human peripheral blood mononuclear cells that were first preincubated in physiologically relevant concentrations of commonly used premedication drugs and cancer chemotherapies. Clinical results of prochlorpemazine therapy in several cases of psychosis. Peptides from the sensitive half-cystines were isolated from tryptic-peptic digests of free secretory component and sequenced.

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