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Roxtrim (Trimethoprim)

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Roxtrim is a combination of two synthetic (man-made) antibiotics, sulfamethoxazole and trimethoprim. Both drugs reduce the ability of some bacteria to utilize folic acid for growing. Sulfamethoxazole is an anti-bacterial sulfonamide, a sulfa drug.

Other names for this medication:
Bactropin, Biotrim, Ciplin, Cotrimstada, Dotrim, Droxol, Eusaprim, Gantrisin, Groprim, Metrim, Netocur, Novidrine, Onetrim, Primadex, Sepmax, Sulfamethoxazolum, Sulfoprima, Sulphytrim, Sultrim, Trimol, Tripur, Trisul, Urisept, Vanasulf, Zoltrim

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Also known as: Trimethoprim


Sulfamethoxazole and trimethoprim combination is used to treat infections such as urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Roxtrim DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.


Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.


Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Roxtrim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Roxtrim if you are allergic to sulfamethoxazole or trimethoprim, or if you have:

severe liver disease; kidney disease that is not being treated or monitored; anemia (low red blood cells) caused by folic acid deficiency; a history of low blood platelets after taking trimethoprim or any sulfa drug; or if you take dofetilide (Tikosyn).

Do not use Roxtrim if you are pregnant. This medicine could harm the unborn baby or cause birth defects. Use effective birth control, and tell your doctor if you are pregnant or become pregnant.

Do not breastfeed while using this medicine.

This medicine should not be given to a child younger than 2 months old.

To make sure Roxtrim is safe for you, tell your doctor if you have:

kidney or liver disease; a folate (folic acid) deficiency; asthma or severe allergies; a thyroid disorder; malnourishment; alcoholism; high levels of potassium in your blood; porphyria, or glucose-6-phosphate dehydrogenase (G6PD) deficiency; or if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests.

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Distribution of indigenous bacteria in the digestive tract of conventional and gnotobiotic rats. Tracer and freeze-fracture electron microscopy of the ovaries of neonatal rat and adult mouse, rat, rabbit, and primate have revealed the presence of gap junctions between follicle cells and oocytes. Effect of behavioural training on brain transfer RNA methylases. Furthermore, perhaps in this situation a left-handed surgeon does lexapro 10 mg make you gain weight is better prepared than a right-handed one to comfortably carry out the procedure. We consider an example of how the evolution model predicts populations will evolve in response to warming temperatures and shifting resource phenology. Very few new antibiotics with activity against Gram-negative bacteria are under development, and no significantly new Gram-negative antibiotics will be available in the next decade. However, antibiotic therapy alone may be useful for acute cases. Furthermore, hemocytes in response to LPS facilitate clearance of LPS from the hemocoel of medfly. Analysis of vascular responses evoked in the cutaneous circulation of one hand by cooling the contralateral hand.

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This dimension might best be described as a generalized deficiency in coping with life, with resultant feelings of hopelessness and worthlessness. Thus, there were no differences between the experimental and control groups in the numbers of emotional reactions to the conditioned stimulus. 16,16-Dimethyl-PGE2-methyl ester, 10 micrograms/kg in two divided doses or 20 micrograms/kg in four divided doses for 10 days, markedly inhibited the aspirin- or indomethacin-induced gastric and intestinal lesions in mini pigs, respectively. This new pendulum pump has a circular motion produced by gear mechanisms connected to the motor. The specificity of chromium nucleotides as inhibitors of selected kinases. We sought to determine whether an acupuncture technique specially developed for a surgical oncology population (intervention) reduces pain or analgesic use after thoracotomy compared with a sham acupuncture technique (control). Cilia did not appear to be affected by exposure to the drug and were observed both in regions devoid of microvilli and in areas with a well developed brush border. To xenical ireland reviews improve our understanding of the mechanism that couples nucleotide-excision repair to transcription in expressed genes, we have examined the effects of mutations in several different DNA repair genes on the removal of cyclobutane pyrimidine dimers from the individual strands of the induced lactose operon in UV-irradiated Escherichia coli. By contrast, n-alkane-specific alterations of the cellular membrane composition were less distinct. Morphologic revertants of murine sarcoma virus transformed nonproducer BALB-3T3: selective techniques for isolation and biologic properties in vitro and in vivo.

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Essential nurse leader competencies for 2020 include: (i) A global perspective or mindset regarding healthcare and professional nursing issues. Experimental data are presented on reorganizations of intra- and interanalyzer functional connections of neurones in the course of conditioning, by interval cross-histograms of two impulse series, and notions on neuronal organization of local and spread conditioned states are formulated. Bladder cancer risk increased with frequency of cigarette smoking and with deep inhaling. We confirmed the isotype specificity of the binding of the anti-rat IgM and anti-rat IgG coating antibodies and conjugates with the secreted rat antibodies in this assay, and, by inhibition of spot formation with soluble antigen, their specificity for ssDNA and BrMRBC. Acral disturbances of the blood supply and cutaneous microangiopathies may be associated with functional as well as with organic vascular disturbances. suis to the extracellular matrix and non-phagocytic cells via fibronectin binding. Transformation with purified plasmid and chromosomal deoxyribonucleic acid from a clinical isolate of Neisseria gonorrhoeae showed that each of seven loci affecting drug resistance (penA, penB, ery, str, tet, chl, and env) was chromosomal.

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Bone mineralization in obese subjects and in subjects on a reducing diet with occasional short-term fasting. Only Index of Productive Syntax scores distinguished the language abilities of 19 neurologically normal from 10 suspect children. The initial decrease in volume of the primary tumor seems to be a critical parameter for the prediction of progression or stability in patients treated by endocrine manipulation. Interactions between non-adjacent bases may be a factor here, as well as in codon recognition. There was one instance of a recruitment order reversal in a pair of MENT motor units. Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. The similarity of the lesions in the two diseases suggests arava medication reviews a common histogenetic mechanism for the synovial lesions: chronic haemarthrosis.

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Determination of S-phase fractions with the help of PCNA immunofluorescence staining is possible, and probably more reliable than calculation of S-fractions from DNA histograms. Modeling of the dynamics of syphilis morbidity taking into account the effect of the activities of the public health system. Growth hormone responses to hypoglycaemia in women with secondary amenorrhoea. Variations of broncho-alveolar lavage techniques affect cell recoveries. Fluid absorption was inhibited by pre-treatment with guar gum at all glucose concentrations tested. Withdrawal-emergent dyskinesia in patients with schizophrenia during antipsychotic discontinuation. Exposure to several AEDs in utero may have negative effects on neurodevelopment, and polytherapy should, if possible, be avoided in pregnant women. Clustering of integrin receptors during cell adhesion stimulates signal transduction across the cell membrane.

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