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Sulfamethoxazolum (Trimethoprim)
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Sulfamethoxazolum

Sulfamethoxazolum is a combination of two synthetic (man-made) antibiotics, sulfamethoxazole and trimethoprim. Both drugs reduce the ability of some bacteria to utilize folic acid for growing. Sulfamethoxazole is an anti-bacterial sulfonamide, a sulfa drug.

Other names for this medication:
Bacin, Bactelan, Bactricid, Bactron, Bakton, Betam, Bismoral, Broncoflam, Chemitrim, Ciplin, Cotribene, Cotrimox, Cotrimoxazol, Cotripharm, Cotrix, Deprim, Dientrin, Dosulfin, Editrim, Epitrim, Fisat, Forcrim, Gantrisin, Kemoprim, Letus, Megaset, Netocur, Noxaprim, Nufaprim, Octrim, Oriprim, Plocanmad, Sulfamethoxazol, Sulfamethoxazole, Sulfoprima, Sulotrim, Sultrian, Sultrim, Theraprim, Trelibec, Triforam, Trimecor, Trimesulf, Trimethazol, Trimoks, Trimosul, Tripur, Trisulfose, Trizole, Zoltrim

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Also known as: Trimethoprim

Description

Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, including cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

Adults: The usual adult dosage in the treatment of urinary tract infections is 1 Sulfamethoxazolum DS (double strength) tablet or 2 Sulfamethoxazolum tablets every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.

Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.

Overdose

Often, no treatment is needed for an antibiotic overdose. Usually, you'll need to watch for stomach upset and possibly diarrhea. In those cases, you should give extra fluids.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Sulfamethoxazolum are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Sulfamethoxazolum is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency.

Sulfamethoxazolum is contraindicated in pediatric patients less than 2 months of age. Sulfamethoxazolum is also contraindicated in patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.

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Health education through television: some theoretical applications. Optical correlation of multiple tracks of conventional optical-disk data, digitally encoded by transitions in reflectance rather than absolute reflectance, can be improved with a pulse-counting version of the digital-multiplication-by-analog-convolution algorithm, which also avoids analog weighting. Surgical evacuation of the haematoma and excision of the malformation did not produce any modification of the reading deficit, which remained unchanged during a 4-year follow-up. The physiological characteristics of F-wave on the evoked EMG has been investigated and the utility of the objective index on cervical myelopathy was discussed. Both bicarbonate-form and chloride-form MIEX resins showed the greatest removal efficiencies as fresh resin, and removal efficiency decreased with multiple regeneration cycles. Leu-enkephalin provokes naloxone-insensitive pulmonary vasoconstriction. Metabolites decrease the plasma clearance of isosorbide dinitrate in rats. Painful synovitis secondary to gout in the area of a prosthetic hip joint. Although, according to the literature data, rat K cells are present in the duodenum and jejunum and, to a lesser extent, in the ileum, in the present study we observed that those cells were abundant also in all parts of the LI. Transient times required for tumors to achieve thermal equilibrium are computed and shown to depend strongly on tumor size and, to a lesser extent, on blood perfusion rate.

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A more likely explanation is that this reflects increased diagnosis of polycythaemia vera in the blood donor population. A novel application of quaternary ammonium compounds as antibacterial hybrid coating on glass surfaces. The effect of breast biopsy on reactive changes in the axillary lymph nodes. Expression of Sox11 transcription factor in different types of B-cell lymphomas. The following metabolites were isolated, identified and quantitated by HPLC: 1-nitropyrene -4,5- or -9,10-dihydrodiol (K-DHD), N-acetyl-1-aminopyrene ( NAAP ), 1-aminopyrene (1-AMP), 10-hydroxy-1-nitropyrene, 4-, 5-, 6-, 8- or 9-monohydroxy-1-nitropyrene (phenols) and 3-hydroxy-1-nitropyrene. Gas ventilation of the perflubron-filled lung was then performed (PLV).

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Toxic megacolon: ultimate fate of patients after successful medical management. Then we study low-power MAC protocols proposed/investigated for a WBAN with emphasis on their strengths and weaknesses. The measurements of activity were done at the presence of homogenized invasive eggs of Ascaris suum, and the mixture of volatile organic acids C2-C6 (at concentrations of 30.3 and 0.3 mM/l). Parallel molecular biological and biorheological studies on RBC membranes under a variety of conditions can provide the fundamental information required for theoretical modeling of RBC membrane rheology at the molecular level. The GAD mouse is a spontaneous neurological mutant with axonal dystrophy in the gracile tract of the medulla oblongata and spinal cord. Axonal velocities of motor units in the hand and foot muscles of the baboon. Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. Eighteen healthy pigs were randomly divided into 3 groups: resveratrol group, nitroglycerin group and control group. The dosimetry of benzene and its metabolites in the target tissue, bone marrow, depends on the balance of activation processes such as enzymatic oxidation and deactivation processes such as conjugation and excretion.

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The triangular fibrocartilage complex was reconstructed using part of the extensor carpi ulnaris tendon. From January 1995 to June 2007, the authors treated 15 complex aneurysms that were unable to be clipped or coiled. Transplantation-related complications predicted by cytokine gene expression in the mixed lymphocyte culture in allogeneic bone marrow transplants. These functions were improved for ease of use, enhanced visualisation and better interpretation of results. Defective basal release of nitric oxide seems to be secondary to blood pressure increase while impaired agonist-evoked endothelium-dependent vasodilation is probably a primary phenomenon.

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The epidermis of mice consists of three cellular components, i.e., keratinocytes, Langerhans cells (LC), and dendritic epidermal T cells (DETC). This paper develops and applies a theoretically based typology of practice organization to data collected as part of a national survey of 2,398 Canadian physicians conducted in late 1986 and early 1987. No inhibitors or activators of the enzymes were detected in any of the infected cell lines. In hearts with low sympathetic drive (reserpine pretreatment), enzyme leakage was unaffected by propranolol and exacerbated by oxprenolol. The literature was searched using Medline and Cochrane databases. This accounts for its usefulness in the early diagnosis of occult fractures and in fractures not clinically suspected or seen on initial x-ray films in the patient with multiple trauma.

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The fluorescence quenching method may be useful to evaluate the interaction of drug-bilirubin-serum albumin. It seems therefore that progressive laminar and tripartrate organization of auditory regions of STR is reflected in intrinsic, association and thalamic connections. The practical and theoretical importance of the anomaly is commented on briefly. Sex difference of N-Acetyl-beta-D-glucosaminidase activity in the kidney, urine, and plasma of mice. The concentrations of Se in plasma and erythrocytes did not differ between the two groups. Quantitative determination of fibronectin (FN): evaluation of immunoturbidimetric and rate nephelometric techniques for FN assay in the different biologic materials. Clinical evaluation of two glazing agents for composite resin: a preliminary report. The findings support the hypothesis that state laws significantly influence involuntary admission rates and, consequently, clinical practice. These findings provide a parsimonious explanation for the unexpectedly high losses of intertidal herring spawn following the Cosco Busan spill.

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Developmental and functional aspects of grafting of the suprachiasmatic nucleus in the Brattleboro and the arrhythmic rat. The aim of the study was to evaluate the impact of routine intraoperative endoscopy on postoperative complications. We present a case of Haemophilus influenzae lobar pneumonia in the father of a child admitted with acute epiglottitis caused by the same organism. The clinical and radiological findings of 21 dogs with hypertrophic osteodystrophy are described. Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids.

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In vivo studies of ambient hypoxia levels were performed using mice with conditional loss of hypoxia-inducible factor (HIF)-alpha expression in the colon. The donor presented Plasmodium vivax in thick blood smears one month after transplant and was treated according to Brazilian Health Ministry guidelines. We here review recent data showing the clinical utility of brain multimodality monitoring (BMM) for the management of SBI. Cadmium nephrotoxicity is heralded by increased excretion of beta2-microglobulin, retinol binding protein and alpha1-microglobulin, indicative of decreased proximal tubule function. The immunological effects of antipsychotics rebalance partly the immune imbalance and the overweight of the production of the kynurenic acid. Rapid cellular calcium oscillations activate gene expression hours later. Embryologic studies have shown that the caput, unlike the rest of the epididymis, can develop from genital ridge derivatives mainly. When muscle dysplasia was extensive, involving the whole length of the dilated ureter, incidence of associated renal dysmorphism was high in that 12 of 17 ureteral units as such demonstrated either severe renal dysplasia (9) or hypoplasia (3).

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The authors investigated the involvement of mTOR in the pathobiologic profiles of 150 specimens of lung carcinoma by immunohistochemistry and immunoblotting in correlation with the upstream and downstream proteins Akt and p70S6-kinase (S6K), respectively. Criteria for testing the susceptibility of Streptococcus pneumoniae to cefotaxime and its desacetyl metabolite using 1 microgram or 30 micrograms cefotaxime disks. The phenylmalonoyl side-chain derivatives were shown to have an unusual antibacterial spectrum expansion (relative to previously known cephalosporins) to include activity against Serratia marcescens and Pseudomonas aeruginosa. Levels of arginine-vasopressin and oxytocin in the pituitary gland and individual hypothalamic nuclei of the genetically obese Zucker rat. Postexpansion, the patients were stabilized with a removable maintenance plate or a transpalatal arch. Activin-A is a molecule of the TGF superfamily, implicated in liver fibrosis, regeneration and stem cell differentiation.

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Ten Simulium ochraceum were allowed to feed at 10 different sites on 12 Guatemalans with onchocerciasis, and skin snips were taken from six of these sites. An analysis of the responses of 354 hearing-impaired subjects was used to evaluate the performance of each of the 90 items remaining in the Revised Form. The breakthrough point is achieved at 100 BV (bed volume) by a column of 0.6 CG. Hypophosphatemia induced by intravenous administration of Saccharated iron oxide. The P1 protein of Mycoplasma pneumoniae (MP) plays an important role in the pathogenesis of MP pneumonia.

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Role of trace elements in the retina and physical theories on the mechanism of vision. Inhibition of human transitional cell carcinoma in vitro proliferation by fluoroquinolone antibiotics. This may prevent duplication of responses during unimanual tasks and help to coordinate the behavior of both hands during a bimanual task. Stage I lesions showed protein in and around arteriolar walls with no cellular reaction indicating that these were very early lesions and corresponded to the findings using HRP as a tracer. Levels of up to 10 micrograms/ml cholesterol had no effect on ECs or SMCs growth or cytotoxicity. To our knowledge this is the first time that such a therapeutic approach has been used in the treatment of a condition which normally carries a very high mortality. The capacity of IgM mu and L chains, and IgM glycopeptides to inhibit these heterospecific antibodies was determined. We postulate that the pattern of developing mechanical asynchrony described may occur secondary to postnatal changes in ventricular morphology. The author speculates that the capacity for object relations may be a relatively stable dimension of adult personality--a continous that stretches from mature, generative mental health to schizophrenia.

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Determination of heat resistance of Bacillus cereus T spores using a germination ratio. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. New investigation of the effect of toner and its by-products on human health and occupational health management of toner. We present the level of evidence available for each endocrine agent based on its efficacy in advanced breast cancer and a diagram of possible treatment pathways. The suspension should be given preference in patients presenting difficulty in swallowing. A disequilibrium between the median and lateral vastus groups, attributable to innervation, was postulated and subsequently confirmed by electromyography.

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High radial artery origin mistaken for inflow artery obstruction in radiocephalic arteriovenous fistula. Long-term results of vascular surgery of Lerish syndrome in patients with type II diabetes Mellitus. The results confirm that macrophage cytoplasmic movement is a primary cause of remanent-field decay in lungs and that magnetometry can be used to quantify intracellular contractile activity. Laparoscopic adrenalectomy for pheochromocytoma: take the vein last?. A significant improvement in diagnostic proficiency was observed with increasing experience. Within 6 weeks, 8 pathology laboratories were accredited for ISH testing and by September 2008, 2 years after the announcement, 22 ISH testing laboratories were taking part in the national program and almost 20,000 ISH tests had been performed. Physical map of the HLA-A/HLA-F subregion and identification of two new coding sequences. On the other hand, in the group of subcutaneous administration, bevacizumab transits faster to blood pool and is accumulated in subcutaneous tumors and peritoneal nodules.

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Albuminuria and neuropathy in newly detected diabetics: profile and correlation. The patients were followed up for 6-12 months with satisfactory cosmetic results. Influence of maximal effort on the plasma lipids and on some intermediate products of lipid metabolism. Much of the radioactivity in the polyribosomal fraction is EDTA and puromycin sensitive. The possible role of inhibin in the regulation of human ovarian cycle has been discussed. Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors. In order to investigate the signal transduction system that regulates endothelial apoptosis, we studied the effects of several mitogenic factors. It was found that the separated TFR ridges were in agreement with the theoretical dispersion, and the reconstructed signals were highly representative of the individual guided modes as well.

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Through heat stability, dialysis, and fractionation studies, the PL-A2 activating factor in sera was found to be a protein, which had a molecular weight of more than 50 kd and was stable at 56 degrees C. The serious public health implications of these various species of mosquitoes is the possibility of outbreaks of infectious diseases like yellow fever, dengue, which some of these mosquitoes are known to transmit. Aberrant signaling cascades emanating from epidermal growth factor receptor (EGFR) are involved in the complex network of oncogenic signaling in lung carcinomas. The induction of interferon (IF) by lactic dehydrogenase virus (LDV) and the action of exogenous IF on LDV multiplication have been studied in vivo and in vitro. This research compares and contrasts the effect of involuntary job loss and retirement on the mental health of older Americans. Histological examination revealed mild inflammation and malacia in the cerebellum associated with the presence of numerous H.

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